RNA Details
Disease Name
pulmonary fibrosis
Tissue
lung
RNA Symbol
Hipk3
RNA ID
RNA Type
circRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
qRT-PCR; Immunofluorescence; Dual-lucimmunofluorescenceerase Reporter Assay etc.
Target
miR-30a-3p
Pathway
NA
PubMed ID
Title
CircHIPK3 regulates pulmonary fibrosis by facilitating glycolysis in miR-30a-3p/FOXK2-dependent manner
Year
2021
Function
"Next, we detected circHIPK3 and miR-30a-3p expression levels in this model and observed circHIPK3 was up-regulated, while miR-30a-3p was markedly down-regulated in a time-dependent manner. Besides, the lactate levels and the protein expression of Foxk2 and glycolytic enzymes (HK2, PFKM, PKM2, and PDK1) were also upregulated after silica exposure."